期刊
AMERICAN JOURNAL OF PSYCHIATRY
卷 159, 期 8, 页码 1432-1434出版社
AMER PSYCHIATRIC PRESS, INC
DOI: 10.1176/appi.ajp.159.8.1432
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- NIAAA NIH HHS [AA-00161, AA-07611] Funding Source: Medline
Objective: Jews drink less than other Caucasians and have a higher prevalence of ADH2*2, an allele of an alcohol dehydrogenase gene that protects against heavy drinking. The relationship of ADH2 polymorphisms to lifetime maximum number of drinks per occasion was investigated in recent Russian immi- grants to Israel (exposed to heavier drinking in their country of origin), other Israeli Ashkenazis, and Sephardics. Method: Seventy-five randomly sampled Israelis participated in a structured interview. ADH2 was genotyped for 68 subjects. Results: ADH2*2 predicted less drinking; however, associations between ADH2 and drinking appeared to differ across the groups, consistent with differences in environmental exposure to heavy drinking. Conclusions: The findings support a protective effect for ADH2*2 against heavy drinking in Jewish samples but also suggest the importance of environment. Future work should investigate interactions between genes and the environment in larger samples.
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