期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 50, 期 8, 页码 1135-1136出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.50.1135
关键词
magnesium lithospermate B; aldose reductase; fibronectin; Salviae miltiorrhizae Radix; antidiabetics
We developed an effective isolation method of magnesium lithospermate B from Salviae miltiorrhizae Radix and found for the first time that magnesium lithospermate B shows strong in vitro inhibition (IC50=0.04 mum) of aldose reductase (AR), 2.5 times than that of clinically used epalrestat (IC50 = 0.1 mum) and accumulation of fibronectin dose dependantly.
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