期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 30, 期 -, 页码 365-373出版社
PORTLAND PRESS LTD
DOI: 10.1042/bst0300365
关键词
cAMP-dependent protein kinase; N-acetyltransferase; pineal
This paper describes the role 14-3-3 proteins play in vertebrate photoneuroendocrine transduction. 14-3-3 proteins form a complex with arylalkyl-amine N-acetyltransferase (AANAT), the enzyme which turns melatonin production on during the day and off at night. Complex formation is triggered at night by cAMP-dependent phosphorylation of the enzyme, and results in activation and protection against proteolysis. This enhances melatonin production > 10-fold. Light exposure results in dephosphorylation of the enzyme and disassociation from 14-3-3, leading to destruction and a rapid drop in melatonin production and release and circulating levels.
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