期刊
DNA SEQUENCE
卷 13, 期 4, 页码 217-220出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1042517021000021608
关键词
angiotensin converting enzyme; zinc metallopeptidase; chromosome X; RT-PCR
We isolated two mouse cDNA clones which show significant similarities with human angiotensin-converting enzyme-related carboxypeptidase (ACE2). The cDNAs were 2746 and 1995 bp in length and seemed to arise from the same gene by alternative splicing. The longer cDNA encoded a 798-amino acid protein containing the sequence motif conserved among zinc metallopeptidases. Mouse ACE2 showed 83% identity with human ACE2. Northern blot analysis revealed that 2.8- and 2.0-kb transcripts were expressed mainly in the kidney and the lungs. The mouse ACE2 gene was mapped to chromosome x 70.5 cM.
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