SWIM, a novel Zn-chelating domain present in bacteria, archaea and eukaryotes

A previously undetected domain with a CxCx(n) CxH pattern of predicted zinc-chelating residues was identified in a variety of prokaryotic and eukaryotic proteins. These include bacterial ATPases of the SW12/SNF2 family, plant MuDR transposases and transposase-derived Far1 nuclear proteins, and vertebrate MEK kinase-1. This domain was designated SWIM after SW12/SNF2 and MuDR, and is predicted to have DNA-binding and protein-protein interaction functions in different contexts.