期刊
PHYSICS AND CHEMISTRY OF LIQUIDS
卷 40, 期 4, 页码 411-420出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/0031910021000017735
关键词
sulfonamides; solubility; partition coefficient; Yalkowsky-Valvani and Jain-Yalkowsky equations
Semi empirical equation developed by Yalkowsky and Valvani, and another equation extended by Jain and Yalkowsky were used to estimate the aqueous solubility S-w, of some sulfonamides using experimental octanol-water partition coefficients P, entropies of fusion DeltaS(f), and melting points t(m), determined by DSC measurements. The calculated solubilities were compared with those experimentally determined. When experimental DeltaS(f) and t(m) were used, the S-w calculated values were in good agreement in most cases.
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