期刊
NATURE REVIEWS CANCER
卷 2, 期 8, 页码 605-615出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc861
关键词
-
类别
资金
- Telethon [E.1224] Funding Source: Medline
As p53 and its homologue p73 have significant sequence and functional similarities, p73 might also be expected to act as a tumour suppressor However, p73 is activated after DNA damage in a way that is distinct from that of p53. The existence of DeltaNp73 - an isoform of p73 that is encoded by a distinct promoter and that lacks the transactivation domain - further complicates matters. It seems to function as an oncogene by inhibiting both p73- and p53-induced apoptosis. So how can these opposing functions be reconciled in human tumours?.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据