期刊
JOURNAL OF PEDIATRIC SURGERY
卷 37, 期 8, 页码 1177-1182出版社
W B SAUNDERS CO
DOI: 10.1053/jpsu.2002.34467
关键词
enteral nutrition; bacterial contamination; neonatal nutrition
Purpose: The goal of this study was to determine incidence of, and complications resulting from, bacterial contamination of enteral feedings in neonates. Methods: A prospective study of 50 tube-fed neonates was conducted. Infants were bolus fed via an open gravity drained system; demographic and clinical data were gathered. The lumen of the tube was cultured quantitatively after 7 days. All organisms were isolated, identified, frozen, and stored to correlate with clinical cultures. Results: The 50 neonates were fed for a mean of 17.6 days each and represent 125 patient weeks (1 tube per patient per week). A total of 71 of 125 tubes were contaminated (>1,000 colony forming units [CFU]/mL), with a mean 908,173 CFU and 3 different bacteria types. Among formula-fed infants, feeding intolerance occurred in 24 of 32 weeks with contaminated tubes versus 0 of 44 weeks with noncontaminated tubes (P < .05). Contamination occurred in 41 of 48 weeks in patients on H2 antagonists versus 32 of 66 weeks in patients with normal gastric acidity (P < .05). Necrotizing enterocolitis developed in 7 patients; all were fed formula contaminated with greater than 100,000 CFU/mL of Gram-negative bacteria. Four required operation; intraoperative cultures found the same organism as cultured previously in the tube in all 4 infants. Conclusion: Bacterial contamination of enteral feeding occurs frequently, causes significant feeding intolerance, and may contribute to NEC. Copyright 2002, Elsevier Science (USA). All rights reserved.
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