期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 93, 期 2, 页码 705-713出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01274.2001
关键词
lung injury; atelectasis; mechanical ventilation; pressure-volume loop; lung elastance
资金
- NCRR NIH HHS [P20RR15557] Funding Source: Medline
- NHLBI NIH HHS [R01 HL-76004, R01 HL-62746, R01 HL-67273] Funding Source: Medline
Recruitment and derecruitment (R/D) of air spaces within the lung is greatly enhanced in lung injury and is thought to be responsible for exacerbating injury during mechanical ventilation. There is evidence to suggest that R/D is a time-dependent phenomenon. We have developed a computer model of the lung consisting of a parallel arrangement of airways and alveolar units. Each airway has a critical pressure (Pcrit) above which it tends to open and below which it tends to close but at a rate determined by how far pressure is from Pcrit. With an appropriate distribution of Pcrit and R/D velocity characteristics, the model able to produce realistic first and second pressure-volume curves of a lung inflated from an initially degassed state. The model also predicts that lung elastance will increase transiently after a deep inflation to a degree that increases as lung volume decreases and as the lung becomes injured. We conclude that our model captures the time-dependent mechanical behavior of the lung due to gradual R/D of lung units.
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