4.7 Article

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

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NATURE IMMUNOLOGY
卷 3, 期 8, 页码 741-748

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NATURE AMERICA INC
DOI: 10.1038/ni817

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FcepsilonRI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that FcepsilonRI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for its initiation, but is necessary for mast cell degranulation. Lyn-deficiency enhanced Fyn-dependent signals and degranulation, but inhibited the calcium response. Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, FcepsilonRI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases.

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