期刊
GENOME RESEARCH
卷 12, 期 8, 页码 1210-1220出版社
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gr.226802
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资金
- NCI NIH HHS [R33CA81665-01] Funding Source: Medline
- NCRR NIH HHS [P41 RR011823, RR11823-03] Funding Source: Medline
- NHGRI NIH HHS [T32HG000035-05, T32 HG000035] Funding Source: Medline
Short open reading frames (ORFs) occur frequently in primary genome sequence. Distinguishing bona fide small genes from the tens of thousands of short ORFs is one of the most challenging aspects of genome annotation. Direct experimental evidence is often required. Here we use a combination of expression profiling and mass spectrometry to verify the independent transcription of 138 and the translation of SO previously nonannotated genes in the Saccharomyces cerevisiae genome. Through combined evidence, we propose the addition of 62 new g genes to the genome and provide experimental support for the inclusion of 10 previously identified genes.
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