期刊
NEUROPSYCHOPHARMACOLOGY
卷 27, 期 2, 页码 133-142出版社
NATURE PUBLISHING GROUP
DOI: 10.1016/S0893-133X(02)00286-5
关键词
BDNF mRNA; hippocampus; dentate gyrus; footshock stress; psychological stress; male rats
资金
- NIMH NIH HHS [2P01MH25642, MH53199, MH45481] Funding Source: Medline
This study examined the effects of footshock stress and re-exposure to cites previously associated with footshock on expression of brain-derived neurotrophic factor (BDNF) mRNA in the hippocampus of male rats. Exposure to twenty 0.5-s 0.4-mA footshocks co-terminating with 70 dB, 5-s long pure tones over 60 min decreased dentate gyrus BDNF mRNA by 21.5%. Baseline BDNF niRNA levels returned to normal by two days after footshock exposure. Re-exposure for 60 min to the chamber and tones previously paired with 0.4 mA footshock decreased BDNF niRNA by 12%. Re-exposure to the conditioning chamber and tones previously paired with 0.6 mA footshock over 60 min decreased BDNF mRNA by 20.8%. The data suggest that psychological, as well as unconditioned physical stress, can decrease hippocampal BDNF mRNA. Possible implications for stress-related and other neuropsychiatric disorders associated with deficits in hippocampal function and volume, such as depression, post-traumatic stress disorder, and Alzheimer's Disease, are discussed.
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