期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 129, 期 1-2, 页码 186-196出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00176-5
关键词
experimental autoimmune encephalomyelitis; cytokines; indoleamine 2,3-dioxygenase; myelin basic protein; Th1; Th2
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated demyelinating disease of the central nervous system (CNS). Indoleamine 2,3-dioxygenase (IDO) is an enzyme that catabolizes tryptophan, which can result in the death of T lymphocytes. This effect of IDO is inhibited by 1-methyl-tryptophan (1-MT). We used a murine model of EAE to demonstrate; (1) opposing patterns of spinal cord IDO and interferon-gamma (INF-gamma) mRNA expression through the preclinical, acute and remission I phases of EAE; (2) a change in the kynurenine-to-tryptophan (KIT) ratio during these same phases; and (3) 1-MT-induced exacerbation of clinical and histologic disease parameters during EAE. These results suggest that IDO may contribute to the regulation of T cell activity associated with the different phases of this animal model of multiple sclerosis (MS). (C) 2002 Elsevier Science B.V. All rights reserved.
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