期刊
PLANTA MEDICA
卷 68, 期 8, 页码 730-733出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2002-33798
关键词
Simaroubaceae; Brucea javanica; quassinoid; yadanziolide S; X-ray analysis; human promyelocytic leukemia (HL-60); cyclooxygenase-1 (COX-1) and-2 (COX-2) mouse mammary organ culture assay
资金
- NCI NIH HHS [P01-CA-48112] Funding Source: Medline
A new quassinoid, yadariziolide S (1), was isolated from the seeds of the traditional Chinese medicinal herb, Brucea javanica, along with ten known compounds, flazin, bruceine D, yadanziolide B, bruceoside A, yadanziolide S, yadanzigan, glycerol 1,3-bisoleate, azelaic acid, (+/-)-8-hydroxyhexadecanoic acid, and vanillin. Compound 1 is the first quassinoid to have been isolated from B. javanica without a methyleneoxy bridge between C-8 and C-13, and its structure was determined using spectroscopic methods, and confirmed by single-crystal X-ray diffraction. All isolates were evaluated for their potential to induce human promyelocytic leukemia (HL-60) cell differentiation, and to inhibit cyclooxygenase-1 (COX-1), -2 (COX-2), and 7,12-dimethylbenz[a]anthracene (DMBA)-induced lesions in a mouse mammary organ culture model.
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