期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 40, 期 8, 页码 1091-1097出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0278-6915(02)00037-6
关键词
spice; chemoprevention; curcumin; gingerol; capsaicin; intracellular signaling cascades
A wide variety of phenolic substances derived from spice possess potent antimutagenic and anticarcinogenic activities. Examples are curcumin, a yellow colouring agent, contained in turmeric (Curcuma longs L., Zingiberaceae), [6]-gingerol, a pungent ingredient present in ginger (Zingiber officinale Roscoe, Zingiberaceae) and capsaicin, a principal pungent principle of hot chili pepper (Capsicum annuum L, Solanaceae). The chemopreventive effects exerted by these phytochemicals are often associated with their antioxidative and anti-inflammatory activities. Cyclo-oxygenase-2 (COX-2) has been recognized as a molecular target of many chemopreventive as well as anti-inflammatory agents. Recent studies have shown that COX-2 is regulated by the eukaryotic transcription factor NF-kappaB. This short review summarizes the molecular mechanisms underlying chemopreventive effects of the aforementioned spice ingredients in terms of their effects on intracellular signaling cascades, particularly those involving NF-kappaB and mitogen-activated protein kinases. (C) 2002 Elsevier Science Ltd. All rights reserved.
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