期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 16, 期 4, 页码 493-499出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/brbi.2001.0637
关键词
PNMT; epinephrine; thymus; spleen; catecholamines; neuroimmunology; lymphocytes
资金
- NIGMS NIH HHS [1E25GM56620-01] Funding Source: Medline
Catecholamines usually are found in neurons and chromaffin cells of mammals. In this study, surprisingly high levels of the epinephrine synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) were detected in the thymus of young mice. Levels of PNMT activity in the thymus were comparable to levels in the brainstem and were suppressed by the PNMT inhibitor LY134046. PNMT mRNA was localized with in situ hybridization throughout the thymus, but levels were approximately twofold higher in the cortex than in the medulla. PNMT activity was barely detectable in the spleen, and only a few cells expressing PNMT mRNA were located in the marginal zone of the white pulp. These findings suggest that cells in the thymus of young mice have the ability to synthesize epinephrine. (C) 2001 Elsevier Science (USA).
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