期刊
PEPTIDES
卷 23, 期 8, 页码 1479-1483出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(02)00084-0
关键词
hypocretin; immunoflorescence; hypothalamus; brainstem; cat
资金
- NHLBI NIH HHS [HL 60296] Funding Source: Medline
- NIA NIH HHS [AG 04307] Funding Source: Medline
- NIMH NIH HHS [MH 43362] Funding Source: Medline
- NINDS NIH HHS [NS 23426, NS 09999] Funding Source: Medline
Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) are two recently discovered hypothalamic neuropeptides. In the present study, using double immunofluorescent techniques, the co-localization of hcrt-1 and hcrt-2 was examined in neuronal soma and fibers/terminals located, respectively, in the cat hypothalamus and brainstem. In the hypothalamus, all hcrt-1 positive neuronal soma also displayed hcrt-2 immunoreactivity. In the brainstem, both hcrt-1 and hcrt-2 antibodies labeled the same fibers/terminals, indicating that hcrt-1 and hcrt-2 co-localize not only in the neuronal soma (hypothalamus) but also in their fibers/terminals (brainstem). If both peptides are released following neuronal activity, then the distinct effects of these peptides in the brain are likely to depend on the types of postsynaptic receptors that are activated. (C) 2002 Elsevier Science Inc. All rights reserved.
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