期刊
BIOORGANIC CHEMISTRY
卷 30, 期 4, 页码 216-232出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0045-2068(02)00019-6
关键词
imperfectly matched DNA; mismatched DNA; unmatched DNA; abasic DNA; site-selective reactions of DNA; detection of mutations
The last decade has witnessed many exciting scientific publications associated with site-selective reactions of small chemical molecules with imperfectly matched DNA. Typical examples are carbodiimide, hydroxylamine, potassium permanganate, osmium tetroxide, chemical tagging probes, biotinylated, chemiluminescent and fluorescent probes, and all of them selectively react with imperfectly matched DNA. More recently, some therapeutic agents including DNA intercalating drugs and groove binders have been found to promote the in vivo repair system to recognize and repair the mismatch more effectively. The results have established a novel method for detection of mismatches. Development of new chemical reactions for detection of imperfectly matched DNA and mutations is a rapidly growing field and has attracted significant interest of scientists from both chemical and biological fields and it is the main focus of this review. (C) 2002 Elsevier Science (USA). All rights reserved.
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