期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 3, 期 8, 页码 586-599出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm882
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A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function.
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