期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 13, 期 8, 页码 444-461出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0955-2863(02)00205-X
关键词
Alzheimer's disease; antioxidants; glutathione; polyphenols; vitamins; oxidative stress; amyloid beta-peptide; cellular response genes
Alzheimer's disease (AD) brains are characterized by extensive oxidative stress. Additionally, large depositions of amyloid beta-peptide (Abeta) are observed, and many researchers opine that Abeta is central to the pathogenesis of AD. Our laboratory combined these two observations in a comprehensive model for neurodegeneration in AD brains centered around Abeta-induced oxidative stress. Given the oxidative stress in AD and its potentially important role in neurodegeneration, considerable research has been conducted on the use of antioxidants to slow or reverse the pathology and course of AD. One source of antioxidants is the diet. This review examines the literature of the effects of endogenous and exogenous, nutritionally-derived antioxidants in relation to AD. In particular, studies of glutathione and other SH-containing antioxidants, vitamins, and polyphenolic compounds and their use in AD and modulation of A,beta-induced oxidative stress and neurotoxicity are reviewed. (C) 2002 Elsevier Science Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据