期刊
NEUROSCIENCE LETTERS
卷 328, 期 1, 页码 55-59出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(02)00427-5
关键词
ergothioneine; N-methyl-D-aspartate; retinal ganglion cells; antioxidants; free radicals; neurodegeneration
Injection of the glutamate agonist N-methyl-D-aspartate into the vitreous body of the rat eye resulted in a number of morphological changes in the retina. Most apparent was a dramatic reduction in the density and sizes of neurons accompanied by a decrease in amyloid precursor protein and glial fibrillary acidic protein immunoreactivity. Cell counts revealed that 81% of ganglion cells and 43% of non-ganglion cells were lost as a result of the treatment. However, in animals treated with the antioxidant ergothioneine, these figures dropped to 44 and 31%, respectively. Thus, ergothioneine appears to be neuroprotective in this system and the data suggest that antioxidants may provide a useful means of modulating glutamate-based toxicity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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