期刊
BRAIN RESEARCH
卷 945, 期 2, 页码 249-258出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)02811-1
关键词
rostroventrolateral medulla; serotonin; sympathetic nerve activity; raphe nucleus; periaqueductal gray matter; rat
Double-label fluoresence immunohistochemistry was performed to define serotonergic projections from the raphe and midbrain to the sympathoexcitatory region of the rostroventrolateral medulla (RVLM). Immunolabelling of cholera toxin B subunit retrogradely transported from the pressor region of the RVLM was combined with serotonin (5-HT) immunohistochemistry. Major sources of serotonergic input to the RVLM were shown to include the raphe obscurus, raphe pallidus and raphe magnus with a minor contribution from the ventrolateral, lateral and ventral regions of the periaqueductal gray matter, and the dorsal raphe nucleus. Serotonergic modulation of sympathoexcitatory neurons may establish patterns of sympathetic nerve activity evident in many aspects of cardiovascular regulation. (C) 2002 Elsevier Science B.V. All rights reserved.
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