期刊
JOURNAL OF CELL BIOLOGY
卷 158, 期 3, 页码 395-399出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200205044
关键词
translation; picornavirus; rotavirus; cricket paralysis-like virus; start codon selection
类别
资金
- NIAID NIH HHS [AI25105] Funding Source: Medline
- NIGMS NIH HHS [GM55979, R01 GM055979] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
As invading viruses do not harbor functional ribosomes in their virions, successful amplification of the viral genomes requires that viral mRNAs compete with cellular mRNAs for the host cell translation apparatus. Several RNA viruses have evolved remarkable strategies to recruit the host translation initiation factors required for the first steps in translation initiation by host cell mRNAs. This review describes the ways that three families of RNA viruses effectively usurp limiting translation initiation factors from the host.
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