期刊
AMERICAN JOURNAL OF MEDICAL GENETICS
卷 114, 期 6, 页码 659-664出版社
WILEY-LISS
DOI: 10.1002/ajmg.10643
关键词
mu-opioid receptor gene; anxiety; depression; personality; temperament; OPRM1
There is evidence from animal experiments that the mu- and 8-opioid receptors may play a role in anxiety and depression. It might therefore be expected that functional polymorphisms of these genes in humans are associated with anxiety and depression. We investigated a single-nucleotide polymorphism (Asn40Asp) of the mu-opioid receptor gene (OPRM1). This association was investigated in two samples: 1) a cross-sectional survey of 867 community-living adults aged 18-79 years who were assessed for anxiety and depression symptoms and related personality traits; and 2) a longitudinal study of childhood temperament in which 660 children were followed from infancy to the mid-teens and assessed for anxiety-related temperament and behavior problems. The data did not support a role for the Asn40Asp polymorphism in anxiety and depression, despite adequate statistical power to detect small effects. (C) 2002 Wiley-Liss, Inc.
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