期刊
LIFE SCIENCES
卷 71, 期 12, 页码 1351-1360出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0024-3205(02)01860-X
关键词
triacylglycerol-rich lipoproteins; vascular cells; mitogen-activated protein kinase; proliferation; atherosclerosis
Postprandial triacylglycerol-rich lipoproteins (TRL) have been implicated in the pathophysiology of atherosclerosis, but the intracellular processes by which TRL could affect vascular function are still unknown. Incubation of TRL obtained at 2 h postprandial period with vascular smooth muscle cells (VSMC) produced a tyrosine phosphorylation of the extracellular signal-regulated kinases I and 2 (ERK I and ERK2) that belong to the mitogen-activated protein kinase (MAPK) family. The activation of ERK I and ERK2 had a maximum at 15 min, returned to baseline by 60 min, and was partially depleted after incubation of cells with a MAPKK inhibitor (PD 098059). In addition, postprandial TRL did competent VSMC for DNA replication through a MAPK pathway. These effects were dependent of the lipid composition of TRL. Our observations suggest that postprandial TRL can trigger activation of the MAPK pathway and induce a mitogenic response in VSMC in a lipid-dependent fashion. (C) 2002 Elsevier Science Inc. All rights reserved.
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