期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 45, 期 17, 页码 3805-3808出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm020133q
关键词
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The synthesis and evaluation of both the (R)- and (S)-enantioisomers about the 5-position on a tetrahydro-1H-1-benzazepine derivative were described. The absolute configuration of the (R,R)-isomer (10) was determined by X-ray crystallographic analysis. After evaluation of both enantiomers (compounds R-2, S-2) for binding affinity, cAMP accumulation, and an in vivo study using Brattleboro rats, R-2 showed more potent activity as a V-2 receptor agonist than S-2.
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