期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 296, 期 2, 页码 425-428出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0006-291X(02)00906-3
关键词
food restriction; SOCS-3 expression; leptin; leptin resistance; ageing; adiposity; hypothalamus; leptin signaling; insulin resistance; obesity
Aged Wistar rats are characterized by leptin and insulin resistance. The expression of SOCS-3 in hypothalamus increases with ageing. Food restriction during 3 months decreases obesity Lee index in aged rats with respect to their ad libitum aged-mates and brings serum leptin concentrations to values close to those of young rats. Food restriction partially reverts the increases in SOCS-3 mRNA levels associated with ageing. These results suggest that SOCS-3 may be a mediator of hypothalamic leptin resistance in the aged Wistar rat and that the hyperleptinemia associated with ageing is. at least in part, responsible for the increase of SOCS-3 expression in hypothalamus. (C) 2002 Elsevier Science (USA), All rights reserved.
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