期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 12, 期 16, 页码 2197-2200出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(02)00363-3
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A novel class of small molecule human granzyme B inhibitors is reported. Compound 20 has a K-i of 7 nM against human granzyme B and blocks CTL mediated apoptosis with an IC50 of 3 micromolar. (C) 2002 Elsevier Science Ltd. All rights reserved.
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