期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 99, 期 17, 页码 10958-10963出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.162095599
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资金
- NCI NIH HHS [F32 CA076770, F32CA76770] Funding Source: Medline
- NIGMS NIH HHS [R01 GM059446, GM08496, T32 GM008496, GM59446] Funding Source: Medline
A potential of about -0.8 (+/-0.2) V (at 1 M versus normal hydrogen electrode) for the reduction of nitric oxide (NO) to its one-electron reduced species, nitroxyl anion ((NO-)-N-3) has been determined by a combination of quantum mechanical calculations, cyclic voltammetry measurements, and chemical reduction experiments. This value is in accord with some, but not the most commonly accepted, previous electrochemical measurements involving NO. Reduction of NO to (NO-)-N-1 is highly unfavorable, with a predicted reduction potential of about -1.7 (+/-0.2) V at 1 M versus normal hydrogen electrode. These results represent a substantial revision of the derived and widely cited values of +039 V and -0.35 V for the NO/(NO-)-N-3 and NO/(NO-)-N-1 couples, respectively, and provide support for previous measurements obtained by electrochemical and photoelectrochemical means. With such highly negative reduction potentials, NO is inert to reduction compared with physiological events that reduce molecular oxygen to superoxide. From these reduction potentials, the pKa of (NO-)-N-3 has been reevaluated as 11.6 ( 3.4). Thus, nitroxyl exists almost exclusively in its protonated form, HNO, under physiological conditions. The singlet state of nitroxyl anion, (NO-)-N-1, is physiologically inaccessible. The significance of these potentials to physiological and pathophysiological processes involving NO and O-2 under reductive conditions is discussed.
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