期刊
BEHAVIOURAL BRAIN RESEARCH
卷 134, 期 1-2, 页码 291-298出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0166-4328(02)00043-8
关键词
interleukin-1 beta; contextual fear conditioning; consolidation timecourse; corticosterone
Prior research has revealed that treatments that elevate the level of the pro-inflammatory cytokine IL-1beta in the brain, if given after training, impair contextual but not auditory-cue fear conditioning. The present experiments add to these finding by showing that, (a) IL-1beta exerts its effect on contextual fear conditioning by impairing consolidation processes that support the storage of the memory representation of the context: (b) the dorsal hippocampus is a critical site for the effect of IL-1beta; (c) the effect of IL-1beta can not be attributed to its effect on glucocorticoid levels; and (d) IL-1beta injected into dorsal hippocampus either, immediately, 3. or 24 h, but not 48 h, after training produces this impairment. At this time the mechanisms responsible for this impairment are not understood, but may involve late-phase protein synthesis processes associated with LTP, because later consolidation processes are being disrupted. (C) 2002 Elsevier Science B.V. All rights reserved.
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