4.8 Article

An amphiphilic resin-supported palladium catalyst for high-throughput cross-coupling in water

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ORGANIC LETTERS
卷 4, 期 17, 页码 2997-3000

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AMER CHEMICAL SOC
DOI: 10.1021/ol0264298

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The Suzuki-Miyaura coupling of aryl halides (8 varieties) and aryl- or vinylboronic acids (12 varieties) took place in water in the presence of a palladium complex of an amphiphilic polystyrene-poly(ethylene glycol) copolymer resin-supported N-anchored 2-aza-1,3-bis(diphenylphosphino)propane ligand and potassium carbonate to give uniform and quantitative yields of the corresponding biaryls (96 varieties).

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