期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 132, 期 2, 页码 191-203出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1569-9048(02)00069-1
关键词
injury, lung, mechanical ventilation; lung, inflammation; mammals, rabbit; methods, bronchoalveolar lavage; ventilation, mechanical, lung inflammation
We investigated the potential inflammatory reaction induced by mechanical ventilation (MV) using 10 ml/kg tidal volume and no positive end-expiratory pressure (PEEP) in control (C, n = 8), spontaneously breathing (SB, n = 12) and mechanically ventilated (MV, n = 12) rabbits with normal lungs. After 6 h (MV and SB groups) or immediately (C group), lungs were removed for measurement of wet-to-dry (W/D) weight ratio and for bronchoalveolar lavage (BAL). Pulmonary mechanics were also studied. MV animals developed a modest but significant (P<0.01) impairment of arterial blood oxygenation and had higher W/D lung weight ratio than C ones. In MV group, BAL macrophage count was greater (P < 0.05) than in SB one. MV induced an upregulation of MCP-1, TNF-alpha, and IL-1beta gene transcription (mRNAs), without significant elevation of the corresponding protein cytokines in the BAL supernatant, except for MCP-1 (P < 0.05). These data suggest that MV, even using moderate tidal volume, elicits a pro-inflammatory stimulus to the lungs. (C) 2002 Elsevier Science B.V. All rights reserved.
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