期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 93, 期 3, 页码 1159-1167出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01264.2001
关键词
insulin-like growth factor I; hypertrophy; cytokine; calcium
This brief review presents the basic premises suggesting that insulin-like growth factor I (IGF-I), functioning in an autocrine/paracrine mode, is an important mediator of skeletal muscle adaptation. Key intracellular signaling mechanisms associated with ligation of the primary IGF-I receptor are highlighted to illustrate the mechanisms by which IGF-I may promote muscle hypertrophy. In addition, a number of recent findings are presented that highlight the potential for interactions between IGF-I-related signaling pathways and intracellular signaling mechanisms activated by cytokines or hormonal systems.
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