期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 130, 期 1-2, 页码 163-172出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00225-4
关键词
EAE/MS; autoinimunity; immunomodulators; immunochemistry; in vivo animal models
A new orally active drug, laquinimod (ABR-215062), was shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE). Furthermore, leukocyte infiltration into the central nervous system (CNS) was abolished in the laquinimod-treated animals. By direct comparison based on dose and total exposure, laquinimod was approximately 20 times more potent than the immunomodulator roquinimex. Laquinimod also had clear therapeutic effect when given after clinical onset in a chronic relapsing EAE model. It therefore represents a new orally active immumoregulatory drug without general immunosuppressive properties for the treatment of the autoimmune disease multiple sclerosis. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据