期刊
IEEE TRANSACTIONS ON MAGNETICS
卷 38, 期 5, 页码 3231-3233出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMAG.2002.802495
关键词
biocompatibility; biodistribution; magnetic fluid; magnetic resonance; magnetite particles; morphology
In this paper, light microscopy and magnetic resonance were used to investigate the biodistribution of magnetite nanoparticles coated with dimercaptosuccinic acid, after intravenous injection of a single dose in mice. Morphological analysis showed a huge amount of magnetic nanoparticles (MNPs) in the lung 30 min after injection. In contrast to the lung, morphological analysis revealed lower concentration of MNPs in the liver. A progressive decrease of MNPs in both lung and liver was observed from 30 min to 4 hours after intravenous injection. MNPs were not observed in any other organs using morphological analysis. In support to the LM observations MR signals were detected in both lung and liver as early as 5 min after injection. In addition, no MR signal was observed in the blood stream as early as 5 min after injection of the single dose.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据