期刊
PLASMID
卷 48, 期 2, 页码 98-103出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0147-619X(02)00118-X
关键词
Lactobacillus plantarum; tetracycline resistance plasmid; composite structure
The 10,877bp tetracycline resistance plasmid pMD5057 from Lactobacillus plantarion 5057 was completely sequenced. The sequence revealed a composite structure containing DNA from up to four different sources. The replication region had homology to other plasmids of lactic acid bacteria while the tetracycline resistance region, containing a tet(M) gene, had high homology to sequences from clostridium perfringens and Staphylococcus aureus. Within the tetracycline resistance region it Lactobacillus IS-element was found. The remaining part of the plasmid contained three open reading, fratries with unknown functions. The composite structure with several truncated genes suggests a recent assembly of the plasmid. This is the first sequence of an antibiotic resistance plasinid isolated from L. phantarum. (C) 2002 Elsevier Science (USA). All rights reserved.
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