Developments in RNA chemistry, a personal view

This review describes some of the contributions of chemistry to the RNA field with a personal bias towards the phosphorothioate modification and the derivatives at the ribose 2'-position. The usefulness of these modifications is discussed and documented with some examples. (C) 2002 Societe francaise de biochimie et biologie moleculaire/Etditions scientifiques et medicales Elsevier SAS. All rights reserved.