期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 4, 期 5, 页码 442-456出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc010090j
关键词
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A strategy has been developed for the efficient application of automated parallel synthesis to specific aspects of the lead optimization processes employed in drug discovery. The method involves the synthesis of collections of compounds using sets of precursors designed to encompass established medicinal chemistry principles and that have been concurrently optimized with respect to a specific chemical transformation. The strategy is illustrated using an automated Mitsunobu protocol employing sets of aliphatic alcohols and phenols as precursors. The former has been formatted to perform simple alkyl homologation exercises, with the latter being designed for use in diversity-based studies.
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