期刊
NEUROIMAGE
卷 17, 期 1, 页码 29-46出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/nimg.2002.1202
关键词
Alzheimer's disease; semantic dementia; validity; voxel-based morphometry
资金
- Medical Research Council [G116/143] Funding Source: Medline
- Alzheimers Research UK [ART-PhD1999-2] Funding Source: researchfish
- Medical Research Council [G116/143] Funding Source: researchfish
- MRC [G116/143] Funding Source: UKRI
We compared voxel-based morphometry (VBM) with independent accurate region-of-interest (ROI) measurements of temporal lobe structures in order to validate the usefulness of this fully automated and unbiased technique in Alzheimer's disease (AD) and semantic dementia (SD). In AD, ROI analyses appear more sensitive to volume loss in the amygdalae, whereas VBM analyses appear more sensitive to right middle temporal gyrus and regional hippocampal volume loss. In SD, ROI analyses appear more sensitive to left middle and inferior temporal gyrus volume loss, whereas VBM appears more sensitive to regional hippocampal volume loss. In addition the significance of volume reductions was generally less in VBM owing to more stringent corrections for multiple comparisons. In conclusion, the automated technique detects a general trend of atrophy similar to that of expertly labeled ROI measurements in AD and SD, although there are discrepancies in the ranking of severity and in the significance of volume reductions that are more marked in AD. (C) 2002 Elsevier Science (USA).
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