期刊
MOLECULAR AND CELLULAR BIOLOGY
卷 22, 期 18, 页码 6384-6392出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.22.18.6384-6392.2002
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资金
- NIGMS NIH HHS [R37 GM020056, R01 GM020056, GM 20056] Funding Source: Medline
Repair of double-strand breaks by gene conversions between homologous sequences located on different Saccharomyces cerevisiae chromosomes or plasmids requires RAD51. When repair occurs between inverted repeats of the same plasmid, both RAD51-dependent and RAD51-independent repairs are found. Completion of RAD51-independent plasmid repair events requires RAD52, RAD50, RAD59, TID1 (RDH54), and SRS2 and appears to involve break-induced replication coupled to single-strand annealing. Surprisingly, RAD51-independent recombination requires much less homology (30 bp) for strand invasion than does RAD51-dependent repair (approximately 100 bp); in fact, the presence of Rad51p impairs recombination with short homology. The differences between the RAD51- and RAD50/RAD59-dependent pathways account for the distinct ways that two different recombination processes maintain yeast telomeres in the absence of telomerase.
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