期刊
FARMACO
卷 57, 期 9, 页码 715-722出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/S0014-827X(02)01263-6
关键词
4-halobenzylidenmalononitriles; ethyl 4-halobenzylidenmalonates; 4-chloro-1-naphthol; benzo[h]chromenes; benzo[a]anthracenes; antimicrobial activity
The synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported. The key intermediate 3-amino-9-chloro-1-(4-halophenyl)-1H-benzo[h]chromene-2-carbonitrile (3) was obtained by treating 4-halobenzylidenmalononitriles (la-c) and ethyl 4-halobenzylidenmalonates (1d-f) with 4-chloro-1-naphthol (2) in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesized compounds. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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