期刊
FARMACO
卷 57, 期 9, 页码 703-708出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/S0014-827X(02)01264-8
关键词
4-hydroxycoumarins; structure-HIV-1; protease inhibition
The screening of the HIV-1 protease (PR) inhibitory activity (IC-50) of various substituted 3-phenyl-4-hydroxycoumarins, 3-benzyl-4-hydroxyeoumarins, 3-phenoxy-4-hydroxy-coumarins, 3-benzenesulfonyl-4-hydroxycoumarins and 3-(7-coumarinyloxy)-4-hydroxycoumarins was performed. The data indicate the importance of substituents at positions 5 and 7 of the coumarin ring on the inhibitory potency of the HIV-1-PR. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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