期刊
CANCER GENETICS AND CYTOGENETICS
卷 137, 期 2, 页码 133-137出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0165-4608(02)00547-2
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Uterine leiomyomata (UL) are benign tumors affecting many women of reproductive age. Cytogenetic studies have indicated that a significant percentage of leiomyomata have chromosomal rearrangements, including those involving the long arm of chromosome 7. Several candidate genes that map to chromosome 7 have been studied for possible roles in the pathogenesis of these tumors. PCOLCE, a gene whose product is involved in the cleavage of type I procollagen C-propeptide, has been mapped to the critical interval on chromosome 7, band q22. Here we evaluate by reverse-transcriptase polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization the expression and deletion status of PCOLCE in a series of karyotyped uterine leiomyomata. (C) 2002 Elsevier Science Inc. All rights reserved.
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