期刊
JOURNAL OF MOLECULAR EVOLUTION
卷 55, 期 3, 页码 314-321出版社
SPRINGER-VERLAG
DOI: 10.1007/s00239-002-2328-y
关键词
OXA; beta-lactamase; positive selection; gene mobilization
资金
- NIGMS NIH HHS [GM60761] Funding Source: Medline
The OXA genes encode a class of beta-lactamases that confer resistance to a wide range of beta-lactam antibiotics. To determine whether the diversity of the OXA beta-lactamases is the result of recent or ancient events, and to determine whether mobilization of the OXA genes from chromosomes to plasmids occurred recently or long ago, we have constructed a Bayesian phylogeny of the OXA beta-lactamase genes. Analysis of that phylogeny shows that much of the diversity is the result of ancient events and that the OXA genes were mobilized from chromosomes to plasmids on at least two independent occasions that occurred millions of years ago. That observation contradicts the commonly held impression that mobilization of antibiotic resistance genes is strictly the result of modern use of antibiotics.
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