期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 238, 期 1-2, 页码 105-110出版社
SPRINGER
DOI: 10.1023/A:1019963222510
关键词
nuclear factor kappa B; amentoflavone; peroxisome proliferator-activated receptor gamma; cyclooxygenase-2; translocation; signal transduction
类别
Amentoflavone, a biflavonoid with antiinflammatory activity, downregulates COX-2 expression in TNFalpha-activated A549 cells with concomitant inhibition of NF-kappaB mediated signaling cascades. We demonstrate here that amentoflavone inhibits NF-kappaB/DNA binding activity potently along with inhibition of degradation of IkappaBalpha and NF-kappaB translocation into nucleus in TNFalpha-activated A549 cells. This flavonoid upregulates PPAR gamma, a transcription factor involved in repressing many cytokine-induced gene expressions. Hence amentoflavone, a dietary constituent, may be of therapeutic value for several lung diseases where COX-2 plays an important role.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据