期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 283, 期 3, 页码 R732-R738出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00346.2001
关键词
urinary protein excretion; isoprostane; dietary sodium; renal damage
类别
资金
- NCI NIH HHS [CA-68485] Funding Source: Medline
- NHLBI NIH HHS [HL-51971] Funding Source: Medline
- NIDDK NIH HHS [DK-26657] Funding Source: Medline
- NIGMS NIH HHS [GM-15431, GM-42056] Funding Source: Medline
The roles of oxidative stress and renal superoxide dismutase (SOD) levels and their association with renal damage were studied in Dahl salt-sensitive (S) and salt-resistant (R)/Rapp strain rats during changes in Na intake. After 3 wk of a high (8%)-Na diet in S rats, renal medullary Cu/Zn SOD was 56% lower and Mn SOD was 81% lower than in R high Na-fed rats. After 1, 2, and 3 wk of high Na, urinary excretion of F-2-isoprostanes, an index of oxidative stress, was significantly greater in S rats compared with R rats. Plasma F-2-isoprostane concentration increased in the 2-wk S high Na-fed group. After 3 wk, renal cortical and medullary superoxide production was significantly increased in Dahl S rats on high Na intake, and urinary protein excretion, an index of renal damage, was 273 +/- 32 mg/d in S high Na-fed rats and 35 +/- 4 mg/d in R high Na-fed rats (P < 0.05). In conclusion, salt-sensitive hypertension in the S rat is accompanied by marked decreases in renal medullary SOD and greater renal oxidative stress and renal damage than in R rats.
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