期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 130, 期 1-2, 页码 32-45出版社
ELSEVIER
DOI: 10.1016/S0165-5728(02)00205-9
关键词
macrophage; microglia; demyelination; GFP; CD45
资金
- NICHD NIH HHS [HD03110] Funding Source: Medline
- NINDS NIH HHS [NS35372, NS24453] Funding Source: Medline
The contribution of peripheral macrophage was assessed in cuprizone intoxication, a model of demyelination and remyelination in which the blood-brain barrier remains intact. Flow cytometry of brain cells isolated from cuprizone-treated mice revealed an increase in the percentage of Mac-1(+)/CD45(hi) peripheral macrophage. To confirm these results in situ, C57BL/6 mice were lethally irradiated, transplanted with bone marrow from GFP-transgenic mice, and exposed to cuprizone. GFP(+) peripheral macrophages were seen in the CNS after 2 weeks of treatment, and infiltration continued through 6 weeks. While the peripheral macrophages were far outnumbered by the resident microglia, their recruitment across the blood-brain barrier alludes to a potentially important role. (C) 2002 Elsevier Science B.V. All rights reserved.
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