期刊
CURRENT MEDICINAL CHEMISTRY
卷 9, 期 17, 页码 1631-1653出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867023369402
关键词
hydroxamic acids; metalloenzyme inhibitors; zinc metalloproteinases; leukotriene A(4) hydrolases; lipoxigenases; cyclooxygenases; peptide deformilases
A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A(4) hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.
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