期刊
JOURNAL OF IMMUNOLOGY
卷 169, 期 5, 页码 2264-2273出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.169.5.2264
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资金
- NCI NIH HHS [R35-CA47554] Funding Source: Medline
- NIAID NIH HHS [R01-AI48833, R01-AI-48832] Funding Source: Medline
Neonatal microglial cells respond to GM-CSF and M-CSF by acquiring different morphologies and phenotypes. To investigate the extent and consequences of this process, a global gene expression analysis was performed, with significant changes in transcript levels confirmed by biochemical analyses. Primary murine microglial cells underwent substantial expression reprogramming after treatment with GM-CSF or M-CSF with many differentially expressed transcripts important in innate and adaptive immunity. In particular, many gene products involved in Ag presentation were induced by GM-CSF, but not M-CSF, thus potentially priming relatively quiescent microglia cells for Ag presentation. This function of GM-CSF is distinct from its primary function in cell proliferation and survival.
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