期刊
VISION RESEARCH
卷 42, 期 20, 页码 2333-2337出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0042-6989(02)00188-8
关键词
ocular hypertension; model; DBA/2J mouse; retinal ganglion cell survival
资金
- NEI NIH HHS [EY 10009-09] Funding Source: Medline
We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in presenting ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P < 0.0001 analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed Further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension. (C) 2002 Elsevier Science Ltd. All rights reserved.
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